Effect of 7-nitro indazole on neurotransmission in the rat vas deferens: mechanisms unrelated to inhibition of nitric oxide synthase
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منابع مشابه
Sleep and nitric oxide: effects of 7-nitro indazole, inhibitor of brain nitric oxide synthase.
We examined the effect of 7-nitro indazole (7-NI, 2.5-50 mg/kg, i.p.), an inhibitor of central nitric oxide (NO) synthesis, on general behaviour and sleep. The results show that 7-NI induces ptosis, a loss of the righting reflex and decrease of the EEG amplitudes. Furthermore, a duration of slow wave sleep (SWS) and REM sleep decreased, while the latencies of SWS and REM sleep increased. The ef...
متن کامل7-Nitro Indazole, a Neuron-specific Nitric Oxide Synthase Inhibitor, Produces Amnesia in the Chick
7-Nitro i n d a z o l e (7-NI), w h i c h is se lec t ive for t h e n e u r o n a l i s o f o r m of n i t r i c ox ide s y n t h a s e (NOS), was t e s t ed in a pass ive a v o i d a n c e task in t he ch ick . I n j ec t i on o f 50 m g / k g i.p. p r e t r a i n i n g h a d a m n e s i c effects for t he task w h e n t e s t ed 30 m i n , 2 o r 24 h r af ter t r a in ing . I n j ec t i ons p...
متن کامل7-Nitro indazole, a neuron-specific nitric oxide synthase inhibitor, produces amnesia in the chick.
7-Nitro indazole (7-NI), which is selective for the neuronal isoform of nitric oxide synthase (NOS), was tested in a passive avoidance task in the chick. Injection of 50 mg/kg i.p. pretraining had amnesic effects for the task when tested 30 min, 2 or 24 hr after training. Injections post-training had no effect. Because 7-NI does not inhibit the endothelial isoform of NOS, it does not affect blo...
متن کامل7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures.
7-Nitro indazole (25-100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory an...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1994
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1994.tb16206.x